Amniotic Band Syndrome Pregnancy Complication

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Amniotic band syndrome is a condition in which fibrous bands of tissue from a pregnant person's uterus wrap around a growing fetus. These bands can constrict a baby's developing fingers, toes, arms, or legs. Rarely, they can wrap around the head, abdomen, or umbilical cord. Amniotic band syndrome occurs in one in every 1,200 to 15,000 births.

Other names for amniotic band syndrome are:

  • ADAM sequence
  • Amniotic banding
  • Amniotic sequence syndrome
  • Constriction ring syndrome
  • Streeter bands


Amniotic band syndrome arises from a structural problem with the amniotic sac that develops during pregnancy. The amniotic sac is a fluid-filled bubble inside the uterus in which your baby floats as they grow during your pregnancy.

It's thought that a spontaneous rupture or tearing of the amniotic sac during the first 20 weeks of pregnancy is what causes the amnion, the sac's inner layer, to break and create strands. These strands can stick to and cross over parts of your baby, sort of like rubber bands around a ball, inhibiting growth, blood flow, or both.

Potential Effects

How early these bands develop usually determines how severe the complications will be for your baby. Generally, the earlier these bands begin to grow, the more time a body part is constricted, which is associated with more serious complications. These complications include:

  • Abdominal wall disorders
  • Cleft lip and/or palate (split in the lip or palate)
  • Club hands or club feet (turning inward of the hands or feet)
  • Constriction of the umbilical cord (when blood supply to the umbilical cord is cut off, which can be fatal)
  • Constriction rings or loss of body parts (fingers, toes, arms, or legs)
  • Encephalocele (a neural tube defect in which part of the brain extrudes through the skull)
  • Face or skull deformities
  • Thoracoschisis (constriction of the thoracic wall)

When amniotic banding develops later, complications are often relatively minor. A baby might have very subtle banding around a finger or toe, for instance. Concerns, if any, are mainly cosmetic.

Risk Factors 

While research points to an early rupturing or tearing of the amniotic sac as the likeliest cause of amniotic band syndrome, scientists are still trying to figure out what puts a pregnant person at risk for such an occurrence.

Some research has pointed to a genetic link, as babies with first-degree relatives with amniotic band syndrome are more likely to have it themselves. There also seems to be a correlation between certain activities and conditions during pregnancy and an increased risk for amniotic band syndrome. These potential risk factors include:


When the effects are subtle, amniotic band syndrome is often discovered after a baby is born. However, some cases can be identified during a routine ultrasound during pregnancy.

If your doctor suspects amniotic band syndrome during your pregnancy, they might recommend additional testing to more definitively diagnose the issue. Possible follow-up tests include:

  • Anatomy ultrasound: This higher-resolution ultrasound can reveal malformations more clearly and assess blood flow.
  • Fetal MRI: An MRI can assess the extent of the complications caused by the amniotic band.
  • Fetal echocardiogram: This specialized ultrasound assesses fetal heart function, which can give a doctor clues about your baby's circulation.


Currently, there is no clear-cut way to prevent amniotic band syndrome from occurring. However, it's important to talk to your doctor early in your pregnancy if you have a family history of amniotic band syndrome or you have possible risk factors for developing it, like diabetes or if you smoke or use drugs.

Your doctor can give you general recommendations for a healthy pregnancy that may reduce your baby's vulnerability to birth defects in general. This is usually a part of preconception care.


There are two potential ways to correct amniotic band syndrome: before birth via fetal surgery and after birth with a variety of surgeries and therapies. In the vast majority of cases, amniotic band syndrome is not treated until after birth.

Fetal Surgery Before Birth

In cases when amniotic banding is constricting the umbilical cord or cutting off the blood supply to a baby's limb, a doctor can attempt to surgically remove the bands before your baby is born. In fetoscopic amniotic band resection, surgeons are guided by ultrasound imagery to use a laser or other surgical instrument to cut the constrictive tissue.

Studies of babies with limbs affected by the condition show that 75% gain functional limbs after fetoscopic amniotic band resection. Since all surgeries carry added risks, this procedure is usually reserved for the most severe cases of amniotic band syndrome.

Surgery and Treatments After Birth

Once babies are born, amniotic banding can be corrected through plastic surgery. Surgeons will release the constrictive tissue and repair the surrounding skin. Unless the constrictive banding is severe enough to pose serious harm to your baby, this procedure is usually done after your child's first birthday.

Sometimes, babies will need occupational therapy to regain strength and coordination in a body part affected by amniotic banding. If a limb is lost as a result of the condition, prosthetics are usually introduced. Because of exciting advances in prosthetics, children can regain full function in these limbs by toddlerhood—as early as 12 to 18 months of age.

Often, there is no need to fix amniotic band syndrome. Bands that are shallow and don't interfere with your child's functioning may be left alone. Whether or not to treat a mild case of amniotic band syndrome is a conversation you should have with your child's doctors as soon as the condition is diagnosed.

A Word From Verywell

Even though amniotic band syndrome is usually well managed through expert observation and helpful treatments, it's natural for parents to experience emotional and even social stress. Because there are not a lot of other infants who have these issues, finding support from parents who are or have been in your situation can be extremely helpful.

Fetal centers that specialize in surgery to treat amniotic band syndrome often host support networks for parents. You can search online for resources, too. There are several active Facebook groups for families of children with amniotic band syndrome and birth defects in general. Sharing knowledge and stories can help you feel connected as well as more empowered during an uncertain time.

6 Sources
Verywell Family uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Gandhi M, Rac MWF, McKinney J. Amniotic band sequenceAmerican Journal of Obstetrics and Gynecology. 2019;221(6):B5-B6. doi:10.1016/j.ajog.2019.09.020.

  2. Nationwide Children's Hospital. What is amniotic band syndrome (ABS)?

  3. Cignini P, Giorlandino C, Padula F, Dugo N, Cafà EV, Spata A. Epidemiology and risk factors of amniotic band syndrome, or ADAM sequenceJ Prenat Med. 2012;6(4):59-63. PMID:23272276

  4. Gueneuc A, Chalouhi GE, Borali D, Mediouni I, Stirnemann J, Ville Y. Fetoscopic release of amniotic bands causing limb constriction: case series and review of the literatureFetal Diagn Ther. 2019;46(4):246-256. doi:10.1159/000495505.

  5. Texas Children's Hospital. Amniotic band resection.

  6. Boston Children's Hospital. Amniotic band syndrome.

Additional Reading

By Robin Elise Weiss, PhD, MPH
Robin Elise Weiss, PhD, MPH is a professor, author, childbirth and postpartum educator, certified doula, and lactation counselor.