Misoprostol Medication for Managing Miscarriage

How medical management of miscarriage works

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In the past few years, it's become more common for doctors to offer medications to manage a miscarriage when hCG results or ultrasound tests confirm the diagnosis of either a missed miscarriage or blighted ovum. This gives women an alternative to a dilation and curettage procedure (D&C) or a potentially long wait for a miscarriage to begin naturally.

Misoprostol for Managing Miscarriage

The most common drug used for this purpose is a medication called misoprostol (brand name Cytotec), which is labeled as an ulcer medication but has been found to be helpful in miscarriage management.

Misoprostol is sometimes used in combination with mifepristone, an antiprogesterone drug that is also known as Mifeprex or RU486. Another possibility is gemeprost, but this drug may trigger more severe side effects in some cases.

Doctors may also use a medication to end a confirmed ectopic pregnancy that is not posing an imminent risk to the woman's health, but the drug, in this case, is usually methotrexate.

Misoprostol in the First Trimester

Medical management of miscarriage makes the most sense in cases where the miscarriage is confirmed but the bleeding has not yet started. How it works: Your doctor prescribes one or more medications that cause your cervix to dilate and your uterine lining to shed. This medication may be oral or vaginal, depending on the specific protocol. The miscarriage-related vaginal bleeding usually begins within a day or two of the administration of the drug and progresses similarly to a natural miscarriage.

Side effects of the drugs can include pain, nausea, vomiting, and diarrhea.

According to research, the success rate for completing a miscarriage after using misoprostol is roughly 71 percent to 84 percent. The majority of women who choose medical management for their miscarriages are satisfied with the choice when interviewed later.

Risks of Using Medication to Manage a Miscarriage

The risks of using medication to expedite a miscarriage (rather than having a D&C) are about the same as the risks of miscarrying naturally. There's a small chance of hemorrhage, infection, and needing a D&C later on if tissue remains in the uterus. Obviously, a D&C carries some small risks also, so the choice is up to you and your doctor—except in those cases where medical emergency necessitates a D&C. Length of bleeding for a medically induced miscarriage is about the same as for a miscarriage that happens without intervention (about two weeks).

Not every doctor offers medical management for first trimester miscarriages at this time, but many do. If you have been diagnosed with a miscarriage and have not yet made a treatment decision, talk to your doctor if you want to explore medical management of miscarriage. These medications should be used only under a physician's supervision.

Second Trimester Use of Misoprostol

Doctors may also prescribe misoprostol, sometimes alongside mifepristone, to induce an impending stillbirth or second-trimester miscarriage when an ultrasound reveals a baby with no heartbeat or otherwise definitive evidence that a pregnancy is not viable.

In these cases, the experience is basically an induction of labor and women will most likely need to check into a hospital for the procedure, whereas medical induction of first trimester miscarriages can often be done on an outpatient basis.


Niinimäki M, Mentula M, Jahangiri R, Männistö J, Haverinen A, Heikinheimo O. Medical Treatment of Second-Trimester Fetal Miscarriage; a Retrospective Analysis. Dangal G, ed. PLoS ONE. 2017;12(7):e0182198. doi:10.1371/journal.pone.0182198.

Saraswat L, Ashok PW, Mathur M. Medical Management of Miscarriage. The Obstetrician & Gynaecologist. 2014;16:79–85.

Tulandi T, Al-Fozan HM. Spontaneous Abortion: Management. UpToDate. Updated August 7, 2017.