Pregnancy Loss Pregnancy Loss Causes and Risk Factors Miscarriage and Stillbirth Causes There Are a Few Known Causes for Pregnancy Loss, but Many Questions Still Remain By Krissi Danielsson Krissi Danielsson Krissi Danielsson, MD is a doctor of family medicine and an advocate for those who have experienced miscarriage. Learn about our editorial process Updated on April 28, 2020 Medically reviewed by Brian Levine, MD, MS, FACOG Medically reviewed by Brian Levine, MD, MS, FACOG Brian Levine, MD, MS, FACOG, is board-certified in obstetrics-gynecology, as well as reproductive endocrinology and infertility (REI). He is the director and founding partner of CCRM New York and was named a rising star by Super Doctors from 2017 to 2019. Learn about our Medical Review Board Print Bruce Ayres/The Image Bank/Getty Images After a pregnancy loss, most couples want answers. Many people wonder if the loss happened because of something they did, or if the miscarriage or stillbirth could have been prevented somehow. Usually, the answer to that question is no. Miscarriage and stillbirth are rarely anyone's fault, and sometimes pregnancy loss is even a predetermined outcome at the time of conception. Even though we know pregnancy loss usually does not happen because of anything the mother (or father) did, doctors cannot always explain why they do happen. What Causes a Miscarriage? Sporadic, one-time pregnancy losses are often caused by random chromosomal abnormalities in the developing baby. The medical community widely recognizes this explanation. In many cases, doctors assume this as the default explanation for first time miscarriages—with good reason, given that most couples go on to have a normal pregnancy after one miscarriage. In most cases, a pregnancy lost to miscarriage has a problem in the chromosomes, such as extra chromosomes or missing chromosomes that cause the pregnancy to stop developing and eventually be miscarried. Because chromosomal flaws are usually random, one-time events, most doctors do not initiate testing for miscarriage causes after the first miscarriage. Anyone can have a miscarriage due to chromosomal flaws, regardless of age, but the highest risk for this particular problem is with mothers aged 35 years or older. While chromosomal abnormalities are the most common cause of miscarriage, there are other things that can result in miscarriage. These include: problems with the structure of the uterus blood clotting disorders in the mother, such as antiphospholipid syndrome smoking or drug use maternal health problems like uncontrolled high blood pressure, diabetes, or autoimmune diseases infection in the mother trauma (for example, physical abuse) The earlier a miscarriage happens in a pregnancy, the more likely it is due to a chromosomal problem. Miscarriages during the second trimester are less common than during the first trimester. What Causes Recurrent Miscarriages? Two miscarriages qualify as recurrent miscarriages, and after three repeat miscarriages, testing is recommended, according to the American College of Obstetricians and Gynecologists. Approximately one percent of women experience repeat miscarriages. About 25 to 50 percent the time, doctors can find a cause for recurrent miscarriages and the woman can be treated in her next pregnancy. But in about 50 to 75 percent of cases, tests do not reveal a cause. But even with recurrent miscarriages, a woman can get pregnant again and still have greater statistical odds of a normal pregnancy than another loss. Widely recognized causes of recurrent miscarriages include the following: Problems with the structure of the uterus Blood clotting disorders, such as antiphospholipid syndrome Other maternal health conditions, like diabetes mellitus or polycystic ovarian syndrome Certain chromosomal conditions, such as balanced translocation What Causes Stillbirth? Stillbirths (pregnancy loss after the 20th week) usually have different causes from earlier miscarriages, although chromosomal errors in the baby can cause stillbirths. Other common causes of stillbirth are cervical insufficiencies, placental problems, infection, blood clotting disorders in the mother, and uterine abnormalities. Support After a Miscarriage or Stillbirth Your doctor should be able to give you information on whether you need testing for pregnancy loss risk factors and causes. Regardless of the cause, if you have had a miscarriage or a stillbirth, be sure to seek out emotional support from friends and relatives or look for support groups if you don't have an adequate support structure. You should not have to go through this alone. Sources Verywell Family uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Michels TC, Tiu AY. Second trimester pregnancy loss. Am Fam Physician. 2007 Nov 1;76(9):1341-46. The American College of Obstetricians and Gynecologists. (August 2015). Frequently Asked Questions: Early Pregnancy Loss. The American College of Obstetricians and Gynecologists. (May 2015). Practice Bulletin: Early Pregnancy Loss. The American College of Obstetricians and Gynecologists. (May 2016). Frequently Asked Questions: Repeated Miscarriages. By Krissi Danielsson Krissi Danielsson, MD is a doctor of family medicine and an advocate for those who have experienced miscarriage. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit